One person was taken to the hospital with serious injuries after a vehicle traveled over the guardrail and rolled on the I-10 near Avondale Boulevard, according to DPS.
Officials say two SUV's collided sending one of the vehicles over the guardrail.
Troopers say a man was arrested for DUI and suffered minor injuries.
I-10 eastbound was closed at Dysart Road for several hours due to the crash.
No further information was immediately available.